5-PH-IAA-AM

5-Ph-IAA-AM is an eggshell-permeable 5-Ph-IAA analog which contains an acetoxymethyl (AM) group. 5-Ph-IAA-AM affords an enhanced protein degradation in laid embryos. 5-Ph-IAA-AM can be used to disclosure the roles of proteins in C. elegans, in particular those that are involved in embryogenesis and development, through temporally controlled protein degradation.


Cat. No.: EX-A11661	Purity: >98%

	Chemical structure of 5-PH-IAA-AM

For research only, Do not use for Human!

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CAS No.	2990123-10-7
Purity	>98%
Formula	C19H17NO4
Mol Weight	323.3426
Color	White to off-white
State	Solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Negishi T, et al. The auxin-inducible degron 2 (AID2) system enables controlled protein knockdown during embryogenesis and development in Caenorhabditis elegans. Genetics. 2022 Feb 4;220(2):iyab218. [2]. Goldner AN, et al. Evidence that tissue recoil in the early Drosophila embryo is a passive not active process[J]. Mol Biol Cell. 2023 Sep 1;34(10):br16. [3]. Eijlers P, et al. A nematode-specific ribonucleoprotein complex mediates interactions between the major nematode spliced leader snRNP and its target pre-mRNAs. Nucleic Acids Res. 2024 Jul 8;52(12):7245-7260.
CoA	CoA of 5-PH-IAA-AM

Smiles:	CC(=O)OCOC(=O)CC1=CNC2=C1C=C(C=C2)C3=CC=CC=C3


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