5-beta-Cholanic Acid

5β-Cholanic acid is a hydrophobic modifier used to modify polymer carriers. 5β-Cholanic acid can improve the acid stability, cell penetration efficiency and drug sustained release ability of nanocarriers, and optimize the oral effectiveness of delivered molecules. 5β-Cholanic acid can covalently bind to Glycol chitosan (GC) to form a GC-CA conjugate, which optimizes the hydrophobic anchoring ability of nanoparticles and enables them to be stably adsorbed on the surface of PLGA nanoparticles. Such nanoparticles can resist dissociation in the gastric acid environment and maintain positive charge to enhance endocytic uptake by intestinal epithelial cells (such as Caco-2 cells). 5β-Cholanic acid can be used in the development of drug delivery systems.


Cat. No.: EX-A15519	Purity: >98%

	Chemical structure of 5-beta-Cholanic Acid

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
1g	488	in-stock
5g	1982	in-stock

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Synonyms	5β-Cholanic acid
Synonyms 2	5 Β -cholanic acid
CAS No.	546-18-9
Purity	>98%
Formula	C24H40O2
Mol Weight	360.5732

Reference:	[1]. Weizhi Wang, et al. Improved oral delivery of insulin by PLGA nanoparticles coated with 5 β-cholanic acid conjugated glycol chitosan. Biomed Mater. 2021 Oct 12;16(6). [2]. Li T, et al. Use of glycol chitosan modified by 5beta-cholanic acid nanoparticles for the sustained release of proteins during murine embryonic limb skeletogenesis. J Control Release. 2010 May 21;144(1):101-8.
CoA	CoA of 5-beta-Cholanic Acid

Smiles:	C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(O)=O)([H])[C@@]3([H])[C@]([C@@]4([C@](CCCC4)([H])CC3)C)([H])CC1


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