5-Aza-T-dCyd

5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd) is an orally active DNA methyltransferase I (DNMT1) inhibitor. 5-Aza-4'-thio-2'-deoxycytidine, a sulfur-containing deoxy-cytidine analog, has the potential for DNA hypomethylating and has antitumor effects.


Cat. No.: EX-A13877	Purity: >98%

	Chemical structure of 5-Aza-T-dCyd

For research only, Do not use for Human!

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Synonyms	5-Aza-4'-thio-2'-deoxycytidine
Synonyms 2	NTX-301
CAS No.	169514-76-5
Purity	>98%
Formula	C8H12N4O3S
Mol Weight	244.271
Color	White to off-white
State	Solid
Solubility	DMSO : 25 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Jaideep V Thottassery, et al. Novel DNA methyltransferase-1 (DNMT1) depleting anticancer nucleosides, 4'-thio-2'-deoxycytidine and 5-aza-4'-thio-2'-deoxycytidine. Cancer Chemother Pharmacol. 2014 Aug;74(2):291-302. [2]. Joel Morris, et al. F-aza-T-dCyd (NSC801845), a Novel Cytidine Analog, in Comparative Cell Culture and Xenograft Studies with the Clinical Candidates T-dCyd, F-T-dCyd, and Aza-T-dCyd. Mol Cancer Ther. 2021 Apr;20(4):625-631.
CoA	CoA of 5-Aza-T-dCyd

Smiles:	O[C@H]1C[C@H](N(C=N2)C(N=C2N)=O)S[C@@H]1CO


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