3-[3-methyl-2-oxo-5-(4-{[(1r,4r)-4-{[4-(6-{5-[(methylcyclopropyl)oxy]-1H-indazol-3-yl}pyrimidin-4-yl)piperazin-1Chemicalbook-yl]methyl}cyclohexyl]oxy}hexahydropyridin-1-yl)benzo[d]imidazol-1-yl]hexahydropyridine-2,6-dione

PROTAC LRRK2 Degrader-3 (compound 6) is a PROTAC LRRK2 degrader with a DC50 of 0.17 nM. PROTAC LRRK2 Degrader-3 can be used for research in Parkinson’s disease and inflammation .


Cat. No.: EX-A17418	Purity: >98%

	Chemical structure of 3-[3-methyl-2-oxo-5-(4-{[(1r,4r)-4-{[4-(6-{5-[(methylcyclopropyl)oxy]-1H-indazol-3-yl}pyrimidin-4-yl)piperazin-1Chemicalbook-yl]methyl}cyclohexyl]oxy}hexahydropyridin-1-yl)benzo[d]imidazol-1-yl]hexahydropyridine-2,6-dione

For research only, Do not use for Human!

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CAS No.	3080678-98-1
Purity	>98%
Formula	C44H54N10O5
Mol Weight	802.9636

Reference:	[1].Renner, A. C., et al. RRK2 Degraders for Parkinson’s Disease and Inflammation: Tau and α-Synuclein Degraders for Neurodegeneration. ACS Med. Chem. Lett.
CoA	CoA of 3-[3-methyl-2-oxo-5-(4-{[(1r,4r)-4-{[4-(6-{5-[(methylcyclopropyl)oxy]-1H-indazol-3-yl}pyrimidin-4-yl)piperazin-1Chemicalbook-yl]methyl}cyclohexyl]oxy}hexahydropyridin-1-yl)benzo[d]imidazol-1-yl]hexahydropyridine-2,6-dione

Smiles:	CC1(CC1)OC2=CC=C3C(C(C4=NC=NC(N5CCN(C[C@H]6CC[C@H](OC7CCN(C8=CC(N(C)C(N9C%10C(NC(CC%10)=O)=O)=O)=C9C=C8)CC7)CC6)CC5)=C4)=NN3)=C2

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