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Product Information:

Phenol, 3,5-dimethyl-2-[2-[[(3R)-1-methyl-3-piperidinyl]amino][1,2,4]triazolo[1,5-a]pyrimidin-5-yl]-

NLRP3-IN-93 is an orally active, blood-brain barrier-permeable NLRP3 inhibitor. NLRP3-IN-93 binds to the NACHT domain, blocks inflammasome assembly, and inhibits downstream IL-1β release, without significantly inhibiting various CYP isoforms. NLRP3-IN-93 demonstrates dose-dependent efficacy in mouse models of acute inflammation and Parkinson's disease, and exhibits good tolerability and an acceptable safety window in rats and dogs. NLRP3-IN-93 can be used in research on Parkinson's disease.

Cat. No.: EX-A13503    Purity: >98%
Chemical
Chemical structure of Phenol, 3,5-dimethyl-2-[2-[[(3R)-1-methyl-3-piperidinyl]amino][1,2,4]triazolo[1,5-a]pyrimidin-5-yl]-


For research only, Do not use for Human!

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100mgget quote
1gget quote


CAS No.3055155-53-5
Purity>98%
FormulaC19H24N6O
Mol Weight352.4335
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. He W, et al. Design, Biological Characterization, and Discovery of the Brain-Penetrant NLRP3 Inhibitor Based on a [1,2,4]Triazolo[1,5-a]pyrimidine Scaffold for the Treatment of Central Nervous System Diseases. J Med Chem. 2026 Jul 9;69(13):15766-15785.

CoACoA of Phenol, 3,5-dimethyl-2-[2-[[(3R)-1-methyl-3-piperidinyl]amino][1,2,4]triazolo[1,5-a]pyrimidin-5-yl]-
Smiles:CC1=C(C(O)=CC(C)=C1)C2=NC=3N(C=C2)N=C(N[C@H]4CN(C)CCC4)N3

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