3-benzyl-1-(trans-4-((5-cyanopyridin-2-yl)amino)cycl ohexyl)-1-(4-(4-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro -1,3-dioxoisoindolin-5-yl)piperidin-4-yl)piperazin

ZLC491 is an orally active PROTAC degrader that selectively targets CDK12/CDK13 and exhibits certain oral bioavailability. ZLC491 induces cereblon- and proteasome-dependent selective degradation of CDK12 and CDK13. ZLC491 inhibits the transcription and expression of long genes, and mainly acts on a subset of DNA damage response genes. ZLC491 inhibits the proliferation of various triple-negative breast cancer cells. ZLC491 can be used in research related to triple-negative breast cancer.


Cat. No.: EX-A12409E	Purity: >98%

	Chemical structure of 3-benzyl-1-(trans-4-((5-cyanopyridin-2-yl)amino)cycl ohexyl)-1-(4-(4-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro -1,3-dioxoisoindolin-5-yl)piperidin-4-yl)piperazin

For research only, Do not use for Human!

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CAS No.	3053716-46-1
Purity	>98%
Formula	C48H51FN10O5
Mol Weight	866.9809
Color	Light yellow to yellow
State	Solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Zhou L, et al. Discovery of ZLC491 as a Potent, Selective, and Orally Bioavailable CDK12/13 PROTAC Degrader. J Med Chem. 2024;67(20):18247-18264. [2]. Tian X, et al. Degradation of Cyclin-Dependent Kinase: A New Weapon for Cancer Therapy[J]. Pharmaceutical Fronts, 2025.
CoA	CoA of 3-benzyl-1-(trans-4-((5-cyanopyridin-2-yl)amino)cycl ohexyl)-1-(4-(4-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro -1,3-dioxoisoindolin-5-yl)piperidin-4-yl)piperazin

Smiles:	O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC(F)=C(C2)N4CCC(CC4)N5CCN(CC5)C6=CC=C(N(C(NCC7=CC=CC=C7)=O)[C@@H]8CC[C@@H](NC9=CC=C(C#N)C=N9)CC8)C=C6

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