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9-Oxa-2-thia-3,5,12,19-tetraazatricyclo[12.3.1.14,8]nonadeca-1(18),4,6,8(19),14,16-hexaen-13-one, 11-(bicyclo[1.1.1]pent-1-ylmethyl)-12-[[6-(1,1-dimethylethyl)furo[2,3-b]pyrazin-2-yl]methyl]-6-(2,6-dimethylphenyl)-, 2,2-dioxide, (11R)-

CFTR corrector 18 (Compound I-99) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 18 facilitates the processing and trafficking of CFTR, increasing the number of CFTR on the cell surface. CFTR corrector 18 is promising for research of cystic fibrosis (CF).

Cat. No.: EX-A12600    Purity: >98%
Chemical
Chemical structure of 9-Oxa-2-thia-3,5,12,19-tetraazatricyclo[12.3.1.14,8]nonadeca-1(18),4,6,8(19),14,16-hexaen-13-one, 11-(bicyclo[1.1.1]pent-1-ylmethyl)-12-[[6-(1,1-dimethylethyl)furo[2,3-b]pyrazin-2-yl]methyl]-6-(2,6-dimethylphenyl)-, 2,2-dioxide, (11R)-


For research only, Do not use for Human!

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CAS No.2993441-49-7
Purity>98%
FormulaC38H40N6O5S
Mol Weight692.826
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Alexander Russell Abela, et al. Modulators of cystic fibrosis transmembrane conductance regulator. WO2023196429A1. 2023-10-12.

CoACoA of 9-Oxa-2-thia-3,5,12,19-tetraazatricyclo[12.3.1.14,8]nonadeca-1(18),4,6,8(19),14,16-hexaen-13-one, 11-(bicyclo[1.1.1]pent-1-ylmethyl)-12-[[6-(1,1-dimethylethyl)furo[2,3-b]pyrazin-2-yl]methyl]-6-(2,6-dimethylphenyl)-, 2,2-dioxide, (11R)-
Smiles:C(C12CC(C1)C2)[C@H]3N(CC=4N=C5C(=NC4)OC(C(C)(C)C)=C5)C(=O)C6=CC(S(=O)(=O)NC=7N=C(OC3)C=C(N7)C8=C(C)C=CC=C8C)=CC=C6

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