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Product Information:

1H-Pyrazole-5-carboxamide, N-[(1S)-2,2-dicyclopropyl-1-[[[4-[(1S,2R)-3-[(3R)-3,4-dimethyl-1-piperazinyl]-2-[(2-methoxyacetyl)amino]-1-methyl-3-oxopropyl]-2-fluorophenyl]amino]carbonyl]ethyl]-1-ethyl-

An interleukin 17 inhibitor with IC50 < 0.1 µM.

Cat. No.: EX-A16614    Purity: >98%
Chemical
Chemical structure of 1H-Pyrazole-5-carboxamide, N-[(1S)-2,2-dicyclopropyl-1-[[[4-[(1S,2R)-3-[(3R)-3,4-dimethyl-1-piperazinyl]-2-[(2-methoxyacetyl)amino]-1-methyl-3-oxopropyl]-2-fluorophenyl]amino]carbonyl]ethyl]-1-ethyl-


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
5mg885in-stock
10mg1485in-stock
25mg2485in-stock
50mg3685in-stock
100mg4885in-stock
500mgget quotein-stock


CAS No.2978700-11-5
Purity>98%
FormulaC34H48FN7O5
Mol Weight653.7872
Statesolid
Solubilitysoluble in DMSO
Shelf Life>3 years if stored properly
StoragePowder 4℃, 2 years; -20℃, 3 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1].Dicyclopropyl based IL-17A modulators and uses thereof

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Inventors: Church, Timothy J.; Linsell, Martin S.; Fatheree, Paul R.; Reilly, Maureen; Paulick, Margot G.

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IWorld Intellectual Property Organization WO2023164057 A1 2023-08-31 | Language: English, Database: CAplus

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CoACoA of 1H-Pyrazole-5-carboxamide, N-[(1S)-2,2-dicyclopropyl-1-[[[4-[(1S,2R)-3-[(3R)-3,4-dimethyl-1-piperazinyl]-2-[(2-methoxyacetyl)amino]-1-methyl-3-oxopropyl]-2-fluorophenyl]amino]carbonyl]ethyl]-1-ethyl-
Smiles:[C@H]([C@H](NC(=O)C=1N(CC)N=CC1)C(NC2=C(F)C=C([C@@H]([C@H](C(=O)N3C[C@@H](C)N(C)CC3)NC(COC)=O)C)C=C2)=O)(C4CC4)C5CC5

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