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1H-Isoindole-1,3(2H)-dione, 5-[4-[[1-[4-[[5-bromo-4-[[4-cyclopropyl-2-(dimethylphosphinyl)phenyl]amino]-2-pyrimidinyl]amino]-5-methoxy-2-(1-methyl-1H-pyrazol-4-yl)phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)-

PROTAC EGFR degrader 13 (compound 106) is an EGFR PROTAC degrader with a DC50 of <0.1 μM. PROTAC EGFR degrader 13 has proliferation inhibitory activity on cell Ba/F3-TEL-EGFR-T790M-L858R-C797S with an IC50 of 15.6 nM. PROTAC EGFR degrader 13 can be used for the study of EGFR-related diseases such as cancer .

Cat. No.: EX-A9086G    Purity: >98%
Chemical
Chemical structure of 1H-Isoindole-1,3(2H)-dione, 5-[4-[[1-[4-[[5-bromo-4-[[4-cyclopropyl-2-(dimethylphosphinyl)phenyl]amino]-2-pyrimidinyl]amino]-5-methoxy-2-(1-methyl-1H-pyrazol-4-yl)phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)-


For research only, Do not use for Human!

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CAS No.2861227-35-0
Purity>98%
FormulaC49H55BrN11O6P
Mol Weight1004.909
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Chen Zhang, et al. Phosphonyl derivative, and composition and pharmaceutical application thereof. WO2022228547A1.

CoACoA of 1H-Isoindole-1,3(2H)-dione, 5-[4-[[1-[4-[[5-bromo-4-[[4-cyclopropyl-2-(dimethylphosphinyl)phenyl]amino]-2-pyrimidinyl]amino]-5-methoxy-2-(1-methyl-1H-pyrazol-4-yl)phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)-

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