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Product Information:

1,2,5-Oxadiazol-3-amine, 4-[7-fluoro-1-(3-pyridazinylmethyl)-1H-benzimidazol-2-yl]-

CVN293 is a selective and brain permeable potassium ion (K +) channel KCNK13 inhibtor with IC50s of 41 nM and 28 nM for hKCNK13 and mKCNK13, respectively. CVN293 potently inhibits the NLRP3-inflammasome mediated production of the proinflammatory cytokine IL-1β in microglia .

Cat. No.: EX-A9637T    Purity: >98%
Chemical
Chemical structure of 1,2,5-Oxadiazol-3-amine, 4-[7-fluoro-1-(3-pyridazinylmethyl)-1H-benzimidazol-2-yl]-


For research only, Do not use for Human!

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CAS No.2815296-08-1
Purity>98%
FormulaC14H10FN7O
Mol Weight311.2739
ColorWhite to light yellow
StateSolid
SolubilitySoluble in DMSO
Shelf Life>3 years if stored properly
StoragePowder -20℃ 3 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Roland W. Bürli, et al.Discovery of CVN293, a Brain Permeable KCNK13 (THIK-1) Inhibitor Suitable for Clinical Assessment. ACS Med. Chem. Lett. 2024.

CoACoA of 1,2,5-Oxadiazol-3-amine, 4-[7-fluoro-1-(3-pyridazinylmethyl)-1H-benzimidazol-2-yl]-
Smiles:FC=1C=CC=C2N=C(C3=NON=C3N)N(C12)CC4=NN=CC=C4

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