(R)-4-(5-chloro-7-((3,3-dimethylbutan-2-yl)amino)-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-3,5-difluorobenzonitrile

Microtubule stabilizer-1 (compound 69) is a brain-penetrant microtubule (MT) stabilizer. Microtubule stabilizer-1 increases acetylated α-tubulin (AcTub) levels and prevents the characteristic loss of neuronal MTs that is observed after incubation with Okadaic acid. Microtubule stabilizer-1 can be used for the study of Alzheimer’s disease (AD) and related neurodegenerative tauopathies.


Cat. No.: EX-A11639	Purity: >98%

	Chemical structure of (R)-4-(5-chloro-7-((3,3-dimethylbutan-2-yl)amino)-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-3,5-difluorobenzonitrile

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	508	In-stock
250mg	880	In-stock
500mg	1280	In-stock

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CAS No.	2699937-76-1
Purity	>98%
Formula	C18H17ClF2N6
Mol Weight	390.818
Color	off-white
State	Solid
Solubility	DMSO : 50 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; 4℃, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Oukoloff K, et al. Evaluation of the Structure-Activity Relationship of Microtubule-Targeting 1,2,4-Triazolo[1,5-a]pyrimidines Identifies New Candidates for Neurodegenerative Tauopathies. J Med Chem. 2021 Jan 28;64(2):1073-1102.
CoA	CoA of (R)-4-(5-chloro-7-((3,3-dimethylbutan-2-yl)amino)-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-3,5-difluorobenzonitrile

Smiles:	N([C@@H](C(C)(C)C)C)C1=C(C(Cl)=NC=2N1N=CN2)C3=C(F)C=C(C#N)C=C3F


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