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Product Information:

25CN-NBOH

25CN-NBOH is a highly selective and brain penetrant 5-HT2A receptor agonist (Ki value of 1.3 nM; EC50 value of 2.1 nM). Moreover, 25CN-NBOH was behaviorally active in two mouse models of hallucinogenic effects.

Cat. No.: EX-A5073    Purity: >98%
Chemical
Chemical structure of 25CN-NBOH


For research only, Do not use for Human!

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SynonymsNBOH-2C-CN
CAS No.1391489-32-9
Purity>98%
FormulaC18H20N2O3
Mol Weight312.363
AppearanceSolid powder
SolubilitySoluble in DMSO and water
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Hansen M, et al. Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists. ACS Chem Neurosci. 2014 Mar 19;5(3):243-9.

[2]. Fantegrossi WE, et al. Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT₂A receptors, in mice. Psychopharmacology (Berl). 2015 Mar;232(6):1039-47.

[3]. Jensen AA, et al. Detailed Characterization of the In Vitro Pharmacological and Pharmacokinetic Properties of N-(2-Hydroxybenzyl)-2,5-Dimethoxy-4-Cyanophenylethylamine (25CN-NBOH), a Highly Selective and Brain-Penetrant 5-HT2A Receptor Agonist. J Pharmacol Exp Ther. 2017 Jun;361(3):441-453.
CoACoA of 25CN-NBOH

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