2-Piperidinone, 4-(dimethylamino)-1-[6-[[4-[3-(1-methylethyl)pyrazolo[1,5-a]pyridin-5-yl]-2-pyrimidinyl]amino]-3-pyridinyl]-, (4S)-

GDC-4198 (RGT-419B) is an orally active CDK4/2 inhibitor with desired degrees of selectivity against kinases such as CDK6, CDK9 and GSK3β. GDC-4198 inhibits the activity of cyclin-CDK complexes, blocks phosphorylation of the retinoblastoma protein (pRb), arresting the cell cycle transition from G1 to S phase. GDC-4198 is promising for research of cancers, such as breast cancer (especially hormone receptor-positive, HER2-negative type), lung cancer, and colorectal cancer.


Cat. No.: EX-A11630	Purity: >98%

	Chemical structure of 2-Piperidinone, 4-(dimethylamino)-1-[6-[[4-[3-(1-methylethyl)pyrazolo[1,5-a]pyridin-5-yl]-2-pyrimidinyl]amino]-3-pyridinyl]-, (4S)-

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
1g	get quote	Inquire

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


CAS No.	2531743-46-9
Purity	>98%
Formula	C26H30N8O
Mol Weight	470.5694
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Zhi Xie, et al. Abstract PS16-22: Targeting resistance to current CDK4/6 therapies by RGT-419B, an inhibitor with optimized kinase activity spectrum. Cancer Res (2021) 81 (4_Supplement): PS16-22. [2]. Zhilong Hu, et al. Cdk inhibitors. WO2020224568A1. 2020-11-12. [3]. Xiaotian Zhu, et al. Salt and solid forms of a cdk inhibitor. WO2025103447A1. 2025-05-22.
CoA	CoA of 2-Piperidinone, 4-(dimethylamino)-1-[6-[[4-[3-(1-methylethyl)pyrazolo[1,5-a]pyridin-5-yl]-2-pyrimidinyl]amino]-3-pyridinyl]-, (4S)-

Smiles:	C(C)(C)C1=C2N(C=CC(=C2)C3=NC(NC4=CC=C(C=N4)N5C(=O)C[C@@H](N(C)C)CC5)=NC=C3)N=C1


		Search