Octanediamide, N1-[2,3-dihydro-1-(phenylsulfonyl)-1H-indol-6-yl]-N8-hydroxy-

WMJ-J-09 is an HDAC inhibitor with IC50 values of 7.5 nM (HDAC1), 21.3 nM (HDAC2), 18.4 nM (HDAC3), 90.9 nM (HDAC8), 3.9 nM (HDAC6) and 8715.7 nM (HDAC4). WMJ-J-09 blocks the cell cycle and induces apoptosis in cancer cells. WMJ-J-09 induces cancer cell death through the LKB1-AMPK-p38MAPK-p63-survivin signaling cascade.WMJ-J-09 inhibits HDAC enzyme activity, leading to acetylation of key proteins and thereby regulating cancer cell death. WMJ-J-09 can be used in HCT116 cells and FaDu cells research[1][2].


Cat. No.: EX-A15948T	Purity: >98%

	Chemical structure of Octanediamide, N1-[2,3-dihydro-1-(phenylsulfonyl)-1H-indol-6-yl]-N8-hydroxy-

For research only, Do not use for Human!

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CAS No.	2416914-29-7
Purity	>98%
Formula	C22H27N3O5S
Mol Weight	445.532
Color	White to off-white
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃, 3 years; 4℃, 2 years; In solvent -20℃, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Hanhuang Yu, et al. The hydroxamate based HDAC inhibitor WMJ-J-09 induces [2]. Chia-Sheng Yen, et al. A Novel Hydroxamate-Based Compound WMJ-J-09 Causes Head and Neck Squamous Cell Carcinoma Cell Death via LKB1-AMPK-p38MAPK-p63-Survivin Cascade. Front Pharmacol. 2018 Mar 1. 9:167.
CoA	CoA of Octanediamide, N1-[2,3-dihydro-1-(phenylsulfonyl)-1H-indol-6-yl]-N8-hydroxy-

Smiles:	O=C(NO)CCCCCCC(=O)NC1=CC=C2C(=C1)N(CC2)S(=O)(=O)C=3C=CC=CC3


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