3-Pyrrolidinol, 3-(trifluoromethyl)-1-[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]-, (3S)-; mesylate

SH1573 is an orally active mIDH2 inhibitor. SH1573 has a strong and selective inhibitory effect on mIDH2 R140Q protein (IC50=4.78 nmol/L), and can effectively reduce the production of the carcinogenic metabolite 2-hydroxyglutarate (2-HG) in animal models, cell lines, serum and tumors. SH1573 can be used for the study of acute myeloid leukemia (AML).


Cat. No.: EX-A6900	Purity: >98%

	Chemical structure of 3-Pyrrolidinol, 3-(trifluoromethyl)-1-[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]-, (3S)-; mesylate

For research only, Do not use for Human!

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CAS No.	2376068-96-9
Purity	>98%
Formula	C21H18F9N7O4S
Mol Weight	635.463
Color	Colorless to light yellow
State	Liquid
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Zhiqiang Wang, et al. "Preclinical efficacy against acute myeloid leukaemia of SH1573, a novel mutant IDH2 inhibitor approved for clinical trials in China." Acta Pharmaceutica Sinica B 11.6 (2021): 1526-1540.
CoA	CoA of 3-Pyrrolidinol, 3-(trifluoromethyl)-1-[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]-, (3S)-; mesylate

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