L-Cysteinyl-L-valyl-L-arginyl-L-alanyl-L-arginyl-L-threonyl-L-arginine

CVRARTR is a programmed cell death ligand-1 (PD-L1) antagonist with a KD of 281 nM. CVRARTR induces the internalization of PD-L1 and downregulates PD-L1 on the cell surface. CVRARTR restores cytokine secretion and T cell proliferation in cell CT26. CVRARTR exhibits antitumor efficacy against in CT26 homograft mouse model. CVRARTR can be used in melanoma research .


Cat. No.: EX-A9617	Purity: >98%

	Chemical structure of L-Cysteinyl-L-valyl-L-arginyl-L-alanyl-L-arginyl-L-threonyl-L-arginine

For research only, Do not use for Human!

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Synonyms	CVRARTR
CAS No.	2349354-64-7
Purity	>98%
Formula	C33H64N16O9S
Mol Weight	861.028
Color	White to off-white
State	Solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, sealed storage, away from moisture, 1 year; In solvent -20℃, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Gurung S, et al., Phage display-identified PD-L1-binding peptides reinvigorate T-cell activity and inhibit tumor progression. Biomaterials. 2020 Jul;247:119984. [2]. Moon Y, et al. Anti-PD-L1 peptide-conjugated prodrug nanoparticles for targeted cancer immunotherapy combining PD-L1 blockade with immunogenic cell death. Theranostics. 2022 Jan 31;12(5):1999-2014.
CoA	CoA of L-Cysteinyl-L-valyl-L-arginyl-L-alanyl-L-arginyl-L-threonyl-L-arginine

Smiles:	[C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)[C@@H](C)O)=O)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CS)N)=O)C(C)C)=O)CCCNC(=N)N)=O)C)=O)CCCNC(=N)N


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