N-[(2-Chloro-6-fluorophenyl)methyl]-5-(1H-indazol-3-yl)-3-thiophenecarboxamide

XMU-MP-9 is a bifunctional compound that binds to the C2 domain of Nedd4-1 and the allosteric site of K-Ras. XMU-MP-9 enhances the interaction between Nedd4-1 and K-Ras, induces conformational changes in the Nedd4-1/K-Ras complex, promotes the ubiquitination and degradation of multiple K-Ras mutants, and inhibits the proliferation of cells carrying K-Ras mutants. XMU-MP-9 can be used for the study of colon, lung and pancreatic cancer .


Cat. No.: EX-A8408	Purity: >98%

	Chemical structure of N-[(2-Chloro-6-fluorophenyl)methyl]-5-(1H-indazol-3-yl)-3-thiophenecarboxamide

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
1g	900
5g	3600

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CAS No.	2251130-41-1
Purity	>98%
Formula	C19H13ClFN3OS
Mol Weight	385.842
Color	white to off-white
State	solid powder
Solubility	DMSO : 116.67 mg/mL
Shelf Life	>1 years if stored properly
Storage	4°C, sealed storage, away from moisture and light
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Taoling Zeng, et al. "Targeting oncogenic K-Ras mutants with a small-molecule degrader through Nedd4-1." bioRxiv (2024): 2024-04.
CoA	CoA of N-[(2-Chloro-6-fluorophenyl)methyl]-5-(1H-indazol-3-yl)-3-thiophenecarboxamide

Smiles:	O=C(C1=CSC(C2=NNC3=C2C=CC=C3)=C1)NCC4=C(F)C=CC=C4Cl


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