2-APQC

2-APQC is an orally active and selective agonist of Sirtuin-3 (SIRT3) (Kd=2.756 μM), antagonizes Isoproterenol/ISO-induced cytotoxicity. 2-APQC activates the SIRT3-PYCR1 axis to enhance mitochondrial proline metabolism and inhibit the ROS-p38MAPK pathway by inhibiting signaling pathways such as mTOR-p70S6K, JNK, and TGF-β/Smad3. 2-APQC also activates the AMPK-Parkin axis to alleviate myocardial hypertrophy and fibrosis and protect cardiac function. 2-APQC can be used in the study of heart failure.


Cat. No.: EX-A12264	Purity: >98%

	Chemical structure of 2-APQC

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	460	In-stock
50mg	730	In-stock
100mg	1150	In-stock
250mg	2350	In-stock
500mg	3760	In-stock
1g	6030	In-stock

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CAS No.	500271-63-6
Purity	>98%
Formula	C23H24FN5O
Mol Weight	405.468
Color	White to off-white
State	Solid
Solubility	DMSO : 50 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Peng F, et al. 2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis. Signal Transduct Target Ther. 2024;9(1):133.
CoA	CoA of 2-APQC

Smiles:	O=C(NCCCCC)C=1C=2N=C3C=CC=CC3=NC2N(C1N)CC4=CC=C(F)C=C4


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