2',2'-cGAMP

2'2'-cGAMP, a synthetic CDN, binds STING in the immune response, inducing IFN-β. 2'2'-cGAMP binds weaker binding to STING than 2'3'-cGAMP but stronger than other CDNs.


Cat. No.: EX-A11802	Purity: >98%

	Chemical structure of 2',2'-cGAMP

For research only, Do not use for Human!

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Synonyms	cGAMP(2'-5')
CAS No.	1465774-27-9
Purity	>98%
Formula	C20H24N10O13P2
Mol Weight	674.4113
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Zhang X, et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell. 2013;51(2):226-235.
CoA	CoA of 2',2'-cGAMP

Smiles:	OC1[C@@]2([C@H](N3C4=C(N=C3)C(=O)N=C(N)N4)O[C@@]1(COP(=O)(O)O[C@@]5([C@H](O)C(COP(=O)(O)O2)(O[C@H]5N6C=7C(N=C6)=C(N)N=CN7)[H])[H])[H])[H]


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