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6-Quinazolinesulfonamide, 1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(1-methyl-1H-pyrazol-4-yl)methyl]-1-(3-oxetanylmethyl)-2,4-dioxo-

a Cell-Active Small Molecule Inhibitor of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG)

Cat. No.: EX-A6138    Purity: >98%
Chemical
Chemical structure of 6-Quinazolinesulfonamide, 1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(1-methyl-1H-pyrazol-4-yl)methyl]-1-(3-oxetanylmethyl)-2,4-dioxo-


For research only, Do not use for Human!

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CAS No.1945951-55-2
Purity>98%
FormulaC21H25N5O5S
Mol Weight459.519
Statesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Waszkowycz, Bohdan ; Smith, Kate M. ; McGonagle, Alison E.; Jordan, Allan M. ; Acton, Ben; Fairweather, Emma E.; Griffiths, Louise A.; Hamilton, Niall M.; Hamilton, Nicola S.; Hitchin, James R.; et al. Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides. Journal of Medicinal Chemistry (2018), 61(23), 10767-10792.
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