1843U89

OSI-7904L (GW1843; 1843U89; OSI-7904) is a thymidylate synthase (TS) inhibitor with a Ki of 90 pM. OSI-7904L blocks de novo synthesis of thymidine nucleotides, DNA synthesis and induces cell death. OSI-7904L inhibits the growth of human cells, induces tumor regression, and achieves durable antitumor effects in mouse xenograft models. OSI-7904L can be used in research related to colon adenocarcinoma.


Cat. No.: EX-A12256	Purity: >98%

	Chemical structure of 1843U89

For research only, Do not use for Human!

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Synonyms	OSI-7904L free acid
CAS No.	139987-54-5
Purity	>98%
Formula	C27H24N4O6
Mol Weight	500.5027
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Desjardins J, et al. Pharmacokinetics, safety, and efficacy of a liposome encapsulated thymidylate synthase inhibitor, OSI-7904L [(S)-2-[5-[(1,2-dihydro-3-methyl-1-oxobenzo[f]quinazolin-9-yl)methyl]amino-1-oxo-2-isoindolynl]-glutaric acid] in mice. J Pharmacol Exp Ther. 2004 Jun;309(3):894-902. [2]. Duch DS, et al. Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase. Cancer Res. 1993 Feb 15;53(4):810-8.
CoA	CoA of 1843U89

Smiles:	O=C1C2=C3C(=CC=C2NC(C)=N1)C=CC(CNC=4C=C5C(=CC4)C(=O)N([C@@H](CCC(O)=O)C(O)=O)C5)=C3


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