15(S)-HpETE

15(S)-HPETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid. It is either metabolized to 14,15-leukotriene A41 or reduced to 15(S)-HETE by peroxidases.2,1 15(S)-HpETE mediates a number of biological functions including the induction of c-fos and c-jun, and activation of AP-1.3 15(S)-HpETE inhibits prostacyclin synthesis in porcine aortic microsomes and bovine endothelial cells, and can cause the suicide inactivation of porcine 12-LO.


Cat. No.: EX-A15329	Purity: >98%

	Chemical structure of 15(S)-HpETE

For research only, Do not use for Human!

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CAS No.	70981-96-3
Purity	>98%
Formula	C20H32O4
Mol Weight	336.4657
Color	Colorless to light yellow
State	Liquid
Shelf Life	>2 years if stored properly
Storage	Solution, -20°C, 2 years
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Soumya SJ, et al. Effect of 15-lipoxygenase metabolites on angiogenesis: 15(S)-HPETE is angiostatic and 15(S)-HETE is angiogenic. Inflamm Res. 2012 Jul;61(7):707-18. [2]. Soumya SJ, et al. 15-LOX metabolites and angiogenesis: angiostatic effect of 15(S)-HPETE involves induction of apoptosis in adipose endothelial cells. PeerJ. 2014 Oct 21;2:e635. [3]. Mahipal SV, et al. Effect of 15-lipoxygenase metabolites, 15-(S)-HPETE and 15-(S)-HETE on chronic myelogenous leukemia cell line K-562: reactive oxygen species (ROS) mediate caspase-dependent apoptosis. Biochem Pharmacol. 2007 Jul 15;74(2):202-14.
CoA	CoA of 15(S)-HpETE

Smiles:	CCCCC[C@@H](/C=C/C=C\C/C=C\C/C=C\CCCC(=O)O)OO


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