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Product Information:

(1R,4R)-N1-(2-Benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido(4,5-b)indol-4-yl)cyclohexane-1,4-diamine

UM171 can enhance human hematopoietic stem cell self-renewal in vitro.

Cat. No.: EX-A7843S    Purity: >98%
Chemical structure of (1R,4R)-N1-(2-Benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido(4,5-b)indol-4-yl)cyclohexane-1,4-diamine


For research only, Do not use for Human!

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CAS No.1448724-09-1
Purity>98%
Statesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Fares, Iman et al. “Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal.” Science (New York, N.Y.) vol. 345,6203 (2014): 1509-12.

[2]. Li, Xuejia et al. “Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human pluripotent stem cells.” Stem cell research vol. 21 (2017): 32-39.

[3]. Ali, Sajjad et al. “Gram-Scale Laboratory Synthesis of UM171, a Potent Agonist of Human Hematopoietic Stem Cell Self-Renewal.” The Journal of organic chemistry vol. 81,21 (2016): 10236-10241.

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