1-[[2-[4-(Dimethylamino)phenyl]-6-quinolinyl]oxy]-3-fluoro-2-propanol

THK-5105, an arylquinoline derivative, displays high binding affinity to tau fibrils. THK-5105 has high binding affinity to tau protein aggregates and tau-rich Alzheimer disease (AD) brain homogenates. 18F-THK-5105 has the potential to act as a tau imaging PET probe .


Cat. No.: EX-A8271A	Purity: >98%

	Chemical structure of 1-[[2-[4-(Dimethylamino)phenyl]-6-quinolinyl]oxy]-3-fluoro-2-propanol

For research only, Do not use for Human!

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CAS No.	1374107-46-6
Purity	>98%
Formula	C20H21FN2O2
Mol Weight	340.3913
Color	Light yellow to yellow
State	solid powder
Solubility	DMSO : 50 mg/mL
Shelf Life	>1 years if stored properly
Storage	4°C, sealed storage, away from moisture and light
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Nobuyuki Okamura, et al. Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease. J Nucl Med. 2013 Aug;54(8):1420-7.
CoA	CoA of 1-[[2-[4-(Dimethylamino)phenyl]-6-quinolinyl]oxy]-3-fluoro-2-propanol

Smiles:	FCC(COC1=CC2=CC=C(C3=CC=C(N(C)C)C=C3)N=C2C=C1)O


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