Benzamide, 5-chloro-2-[4,4,4-trifluoro-3-hydroxy-1,1-dimethyl-3-[[5-(methylsulfonyl)-1H-pyrrolo[2,3-c]pyridin-2-yl]methyl]butyl]-

Glucocorticoid receptor/IL-6-IN-2 (Compound 36) is a selective dual inhibitor targeting the glucocorticoid receptor (GR) and IL-6 signaling pathway (IC50 values of 40 nM and 19 nM, respectively). Glucocorticoid receptor/IL-6-IN-2 is promising for research of inflammatory diseases like rheumatoid arthritis and asthma.


Cat. No.: EX-A13739	Purity: >98%

	Chemical structure of Benzamide, 5-chloro-2-[4,4,4-trifluoro-3-hydroxy-1,1-dimethyl-3-[[5-(methylsulfonyl)-1H-pyrrolo[2,3-c]pyridin-2-yl]methyl]butyl]-

For research only, Do not use for Human!

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CAS No.	1198784-83-6
Purity	>98%
Formula	C22H23ClF3N3O4S
Mol Weight	517.949
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Harcken C, et al. Optimization of drug-like properties of nonsteroidal glucocorticoid mimetics and identification of a clinical candidate. ACS Med Chem Lett. 2014 Nov 20;5(12):1318-23.
CoA	CoA of Benzamide, 5-chloro-2-[4,4,4-trifluoro-3-hydroxy-1,1-dimethyl-3-[[5-(methylsulfonyl)-1H-pyrrolo[2,3-c]pyridin-2-yl]methyl]butyl]-

Smiles:	O=C(N)C1=CC(Cl)=CC=C1C(C)(C)CC(O)(CC2=CC=3C=C(N=CC3N2)S(=O)(=O)C)C(F)(F)F


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