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Product Information:

EPZ5676

Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor with a Ki of 80 pM.

Cat. No.: EX-A316    Purity: >98%
Chemical
Chemical structure of EPZ5676


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg480In-stock
250mg800In-stock
500mg1250In-stock
1g1850In-stock


SynonymsPinometostat
CAS No.1380288-87-8
Purity>98%
FormulaC30H42N8O3
Mol Weight562.7063
Appearancewhite to off-white powder
SolubilitySoluble in DMSO, not in water
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Klaus CR, et al. DOT1L inhibitor EPZ-5676 displays synergistic antiproliferative activity in combination with standard of care drugs and hypomethylating agents in MLL-rearranged leukemia cells. J Pharmacol Exp Ther. 2014 Sep;350(3):646-56.
CoACoA of EPZ5676
Smiles:CC(C)N(C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12)[C@@H]1C[C@H](CCC2=NC3=CC(=CC=C3N2)C(C)(C)C)C1

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