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Product Information:

MK-1775

Adavosertib (MK-1775, AZD1775) is a potent and selective Wee1 inhibitor with IC50 of 5.2 nM in a cell-free assay; hinders G2 DNA damage checkpoint.

Cat. No.: EX-A331    Purity: >=99.5%
MK-1775
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg425In-stock
500mg535In-stock
1g725In-stock
5g1450In-stock
10g2250In-stock
25g3350In-stock


SynonymsAdavosertib
CAS No.955365-80-7
Purity>=99.5%
FormulaC27H32N8O2
Mol Weight500.5954
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Hirai H, et al. Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents. Mol Cancer Ther, 2009, 8(11), 2992-3000.
CoACoA of MK-1775
Smiles:CN1CCN(CC1)C1=CC=C(NC2=NC=C3C(=O)N(CC=C)N(C3=N2)C2=NC(=CC=C2)C(C)(C)O)C=C1

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