R788

Fostamatinib (R788), a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3.


Cat. No.: EX-A108	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	600	In-stock
500mg	850	In-stock
1g	1150	In-stock
5g	2250	In-stock
10g	3350	In-stock

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Synonyms	Fostamatinib
CAS No.	901119-35-5
Purity	>98%
Formula	C23H26FN6O9P
Mol Weight	580.4595
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1] Braselmann S, et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther, 2006, 319(3), 998-1008. [2] Chen L et al. SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma. Blood, 2008, 111(4), 2230-2237. [3] Suljagic M, et al. The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling. Blood, 2010, 116(23), 4894-4905. [4] Bajpai M. Fostamatinib, a Syk inhibitor prodrug for the treatment of inflammatory diseases. IDrugs, 2009, 12(3), 174-185.
CoA	CoA of R788

Smiles:	COC1=CC(NC2=NC=C(F)C(NC3=CC=C4OC(C)(C)C(=O)N(COP(O)(O)=O)C4=N3)=N2)=CC(OC)=C1OC


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