GDC-0152

GDC-0152 is a potent IAPs inhibitor, and binds to the BIR3 domains of XIAP, cIAP1, cIAP2 and the BIR domain of ML-IAP with Ki values of 28 nM, 17 nM, 43 nM and 14 nM, respectively.


Cat. No.: EX-A1658	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	450	In-stock
200mg	700	In-stock
500mg	1050	In-stock
1g	1550	In-stock
5g	4350	In-stock
10g	6500	In-stock

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CAS No.	873652-48-3
Purity	>98%
Formula	C25H34N6O3S
Mol Weight	498.641
Appearance	solid powder
Solubility	DMSO : >50 mg/mL (200.55 mM) Ethanol : 50 mg/mL (100.27 mM; Need ultrasonic)
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Flygare JA, et al. Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152). J Med Chem. 2012 May 10;55(9):4101-13.
CoA	CoA of GDC-0152

Smiles:	CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)NC1=C(N=NS1)C1=CC=CC=C1


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