GRT6005

Cebranopadol (GRT6005) is an analgesic NOP and Opioid Receptor agonist with Kis/EC50s of 0.9 nM/13 nM, 0.7 nM/1.2 nM, 2.6 nM/17 nM, 18 nM/110 nM for human NOP, MOP, KOP and delta-opioid peptide (DOP) receptor, respectively.


Cat. No.: EX-A1095	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	800	In-stock
500mg	1085	In-stock
1g	1585	In-stock
5g	3985	In-stock
10g	5885	In-stock

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Synonyms	Cebranopadol
CAS No.	863513-91-1
Purity	>98%
Formula	C24H27FN2O
Mol Weight	378.4824
Appearance	solid powder
Solubility	DMSO : 6.61 mg/mL (17.66 mM; Need ultrasonic)
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Linz K, et al. Cebranopadol: a novel potent analgesic nociceptin/orphanin FQ peptide and opioid receptor agonist. J Pharmacol Exp Ther. 2014 Jun;349(3):535-48. [2]. de Guglielmo G, et al. Cebranopadol Blocks the Escalation of Cocaine Intake and Conditioned Reinstatement of Cocaine Seeking in Rats. J Pharmacol Exp Ther. 2017 Sep;362(3):378-384. [3]. Satat K, et al. Evaluation of cebranopadol, a dually acting nociceptin/orphanin FQ and opioid receptor agonist in mouse models of acute, tonic, and chemotherapy-induced neuropathic pain. Inflammopharmacology. 2017 Oct 25.
CoA	CoA of GRT6005

Smiles:	CN(C)C1(CCC2(CC1)OCCC1=C2NC2=C1C=C(F)C=C2)C1=CC=CC=C1


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