background


Product Information:

WP1066

WP1066 is an inhibitor of JAK2 and STAT3, and also shows effect on STAT5 and ERK1/2, without affecting JAK1 and JAK3.

Cat. No.: EX-A760    Purity: >98%
WP1066
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg485In-stock
500mg585In-stock
1g785In-stock
2g1150In-stock
5g2500In-stock
10g3760In-stock


CAS No.857064-38-1
Purity>98%
FormulaC17H14BrN3O
Mol Weight356.217
Appearancesolid powder
SolubilitySoluble in DMSO,Ethanol
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Verstovsek S, et al. WP1066, a novel JAK2 inhibitor, suppresses proliferation and induces apoptosis in erythroid human cells carrying the JAK2 V617F mutation. Clin Cancer Res, 2008, (3), 788-796.

[2]. Hatiboglu MA, et al. The tumor microenvironment expression of p-STAT3 influences the efficacy of WP1066 in murine melanoma models. Int J Cancer, 2012, 131(1), 8-17

[3]. Ferrajoli A, et al. WP1066 disrupts Janus kinase-2 and induces caspase-dependent apoptosis in acute myelogenous leukemia cells. Cancer Res, 2007, 67(23), 11291-11299.

CoACoA of WP1066
Smiles:C[C@H](NC(=O)C(=C\C1=NC(Br)=CC=C1)\C#N)C1=CC=CC=C1

KEYWORDS: buy WP1066 | WP1066 supplier | purchase | cost | manufacturer | order | distributor | buy 857064-38-1 | 857064-38-1 supplier