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Product Information:

KW-2478

KW-2478 is a novel and potent nonansamycin inhibitor of heat shock protein 90 (Hsp90) with IC50 of 3.8 nM.

Cat. No.: EX-A035    Purity: >98%
KW-2478
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg695In-stock
250mg1100In-stock
1g2200In-stock
5g6500Inquire


CAS No.819812-04-9
Purity>98%
FormulaC30H42N2O9
Mol Weight574.6625
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Takayuki Nakashima, et al. New molecular and biological mechanism of antitumor activities of KW-2478, a novel nonansamycin heat shock protein 90 inhibitor, in multiple myeloma cells. Clin Cancer Res, 2010, 16(10), 2792-2802.

[2]. Ishii T, et al. Anti-tumor activity against multiple myeloma by combination of KW-2478, an Hsp90 inhibitor, with bortezomib. Blood Cancer J, 2012, 2(4), e68.
CoACoA of KW-2478
Smiles:CCC1=C(O)C=C(O)C(C(=O)C2=CC=C(OCCN3CCOCC3)C(OC)=C2)=C1CC(=O)N(CCOC)CCOC

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