Volasertib

Volasertib (BI-6727) is an orally active, highly potent and ATP-competitive Polo-like kinase 1 (PLK1) inhibitor with an IC50 of 0.87 nM. Volasertib inhibits PLK2 and PLK3 with IC50s of 5 and 56 nM, respectively. Volasertib induces mitotic arrest and apoptosis.


Cat. No.: EX-A1364	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	400	In-stock
250mg	600	In-stock
500mg	850	In-stock
1g	1185	In-stock
5g	2850	In-stock
10g	4225	In-stock

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Synonyms	BI-6727
CAS No.	755038-65-4
Purity	>98%
Formula	C34H50N8O3
Mol Weight	618.8126
Appearance	Solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Xie FF, et al. Volasertib suppresses tumor growth in cervical cancer. Am J Cancer Res. 2015 Nov 15;5(12):3548-59. [2]. Rudolph D, et al. BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity.Clin Cancer Res. 2009 May 1;15(9):3094-102. Epub
CoA	CoA of Volasertib

Smiles:	CC[C@H]1N(C(C)C)C2=NC(NC3=CC=C(C=C3OC)C(=O)NC3CCC(CC3)N3CCN(CC4CC4)CC3)=NC=C2N(C)C1=O


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