Nutlin-3a

Nutlin-3a (Rebemadlin), an active enantiomer of Nutlin-3, is a potent MDM2 (murine double minute 2) inhibitor, with potential antineoplastic activity.


Cat. No.: EX-A1359	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	850	In-stock
250mg	1300	In-stock
500mg	1850	In-stock
1g	2550	In-stock
5g	6850	In-stock
10g	9950	In-stock

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Synonyms	Rebemadlin
CAS No.	675576-98-4
Purity	>98%
Formula	C30H30Cl2N4O4
Mol Weight	581.49
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Crane EK, et al. Nutlin-3a: A Potential Therapeutic Opportunity for TP53 Wild-Type Ovarian Carcinomas. PLoS One. 2015 Aug 6;10(8):e0135101. [2]. Tovar C, et al. Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1888-93.
CoA	CoA of Nutlin-3a

Smiles:	COC1=CC=C(C2=N[C@H]([C@H](N2C(=O)N2CCNC(=O)C2)C2=CC=C(Cl)C=C2)C2=CC=C(Cl)C=C2)C(OC(C)C)=C1


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