GBR 12935 dihydrochloride

GBR 12935 dihydrochloride is a potent, and selective dopamine reuptake inhibitor, with the binding constant (Kd) of 1.08 nM in COS-7 cells. GBR 12935 dihydrochloride stimulates the locomotion activity in different mice strains but fails to induce stereotypy. Thus, GBR 12935 dihydrochloride also prevents the d-Fenfluramine-induced head-twitch response in mice.


Cat. No.: EX-A451	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	350	In-stock
500mg	550	In-stock
1g	880	In-stock
5g	1780	In-stock
10g	2800	In-stock

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Synonyms	GBR 12935 hydrochloride
CAS No.	67469-81-2
Purity	>98%
Formula	C28H36Cl2N2O
Mol Weight	487.504
Appearance	solid
Solubility	DMSO : 25 mg/mL (51.28 mM; Need ultrasonic) H2O : 7.14 mg/mL (14.65 mM; ultrasonic and warming and heat to 60°C)
Shelf Life	>2 years if stored properly
Storage	Powder 4°C, sealed storage, away from moisture; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Hiroi T, et al. Specific binding of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl propyl) piperazine (GBR-12935), an inhibitor of the dopamine transporter, to human CYP2D6. Biochem Pharmacol. 1997 Jun 15;53(12):1937-9. [2]. Rahman S, et al. Negative interaction of dopamine D2 receptor antagonists and GBR 12909 and GBR 12935 dopamine uptake inhibitors in the nucleus accumbens. Eur J Pharmacol. 2001 Feb 23;414(1):37-44. [3]. Tolliver BK, et al. Comparison of cocaine and GBR 12935: effects on locomotor activity and stereotypy in two inbred mouse strains. Pharmacol Biochem Behav. 1994 Jul;48(3):733-9.
CoA	CoA of GBR 12935 dihydrochloride

Smiles:	Cl.Cl.C(CN1CCN(CCOC(C2=CC=CC=C2)C2=CC=CC=C2)CC1)CC1=CC=CC=C1


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