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Pifithrin-alpha hydrobromide

Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist.

Cat. No.: EX-A1162    Purity: >98%
Pifithrin-alpha
For research only, Do not use for Human!

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SynonymsPifithrin-α hydrobromide
Synonyms 2Pifithrin hydrobromide
CAS No.63208-82-2
Purity>98%
FormulaC16H19BrN2OS
Mol Weight367.304
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 3 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Yu W, et al. Cyclosporine A Suppressed Glucose Oxidase Induced P53 Mitochondrial Translocation and Hepatic Cell Apoptosis through Blocking Mitochondrial Permeability Transition. Int J Biol Sci. 2016 Jan 1;12(2):198-209.

[2]. Hoagland MS, et al. The p53 Inhibitor Pifithrin-α Is a Potent Agonist of the Aryl Hydrocarbon Receptor. J Pharmacol Exp Ther. 2005 Aug;314(2):603-10.

[3]. Kuang SQ, et al. FOXE3 mutations predispose to thoracic aortic aneurysms and dissections. J Clin Invest. 2016 Mar 1;126(3):948-61.
CoACoA of Pifithrin-alpha hydrobromide
Smiles:Br[H].CC1=CC=C(C=C1)C(=O)CN1C(=N)SC2=C1CCCC2

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