Staurosporine

Staurosporine (AM-2282, Antibiotic AM-2282, STS) is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM) in cell-free assays. Also shows inhibitory activities on other kinases, such as PKA, PKG, S6K, CaMKII, etc.


Cat. No.: EX-A1777	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	685	In-stock
500mg	885	In-stock
1g	1385	In-stock
2g	2500	In-stock
5g	bulk discount	In-stock
10g	bulk discount	In-stock

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Synonyms	AM-2282
CAS No.	62996-74-1
Purity	>98%
Formula	C28H26N4O3
Mol Weight	466.531
Appearance	Solid powder
Solubility	DMSO 46 mg/mL (98.60 mM); Ethanol Insoluble; Water Insoluble;
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Tamaoki, T et al. Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase. Biochemical and biophysical research communications vol. 135,2 (1986): 397-402. [2]. Meggio, F et al. Different susceptibility of protein kinases to staurosporine inhibition. Kinetic studies and molecular bases for the resistance of protein kinase CK2. European journal of biochemistry vol. 234,1 (1995): 317-22. [3]. Kruman, I et al. Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells. Journal of neuroscience research vol. 51,3 (1998): 293-308. [4]. Tang, D et al. Caspase-8 activation and bid cleavage contribute to MCF7 cellular execution in a caspase-3-dependent manner during staurosporine-mediated apoptosis. The Journal of biological chemistry vol. 275,13 (2000): 9303-7.
CoA	CoA of Staurosporine

Smiles:	CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)N1C3=CC=CC=C3C3=C4CNC(=O)C4=C4C5=CC=CC=C5N2C4=C13


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