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Product Information:

Losmapimod

Losmapimod is a selective, potent, and orally active p38 MAPK inhibitor with pKis of 8.1 and 7.6 for p38α and p38β, respectively.

Cat. No.: EX-A486    Purity: >98%
Losmapimod
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg495In-stock
500mg695In-stock
1g965In-stock
2g1544In-stock
5g2895In-stock
10g4632In-stock


SynonymsGW-856553
CAS No.585543-15-3
Purity>98%
FormulaC22H26FN3O2
Mol Weight383.4591
Appearancesolid powder
SolubilitySoluble in DMSO/Ethanol
Shelf Life>2 years if stored properly
Storage

Powder -20°C, protect from light, stored under nitrogen

The compound is unstable in solutions, freshly prepared is recommended.

ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Willette RN, et al. Differential effects of p38 mitogen-activated protein kinase and cyclooxygenase 2 inhibitors in a model of cardiovascular disease. J Pharmacol Exp Ther. 2009 Sep;330(3):964-70.

[2]. Zhang XM, et al. Suppression of mitochondrial fission in experimental cerebral ischemia: The potential neuroprotective target of p38 MAPK inhibition. Neurochem Int. 2015 Nov;90:1-8.

CoACoA of Losmapimod
Smiles:CC1=C(F)C=C(C=C1C1=CC=C(C=N1)C(=O)NCC(C)(C)C)C(=O)NC1CC1

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