Erastin

Erastin is a ferroptosis inducer. Erastin shows selective cytotoxicity, targeting cells expressing oncogenic mutants of RAS. Erastin exhibits the mechanism of ferroptosis induction related to ROS and iron-dependent signaling. Erastin inhibits voltage-dependent anion channels (VDAC2/VDAC3) and accelerates oxidation, leading to the accumulation of endogenous reactive oxygen species. Erastin also disrupts mitochondrial permeability transition pore (mPTP) with anti-tumor activity.


Cat. No.: EX-A295	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
500mg	595	In-stock
1g	895	In-stock
2g	1500	In-stock
5g	3200	In-stock
10g	4665	In-stock
25g	Get quote	In-stock

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CAS No.	571203-78-6
Purity	>98%
Formula	C30H31ClN4O4
Mol Weight	547.045
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Li Y, et al. Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis. Hum Reprod. 2021 Mar 18;36(4):951-964. [2]. Huo H, et al. Erastin Disrupts Mitochondrial Permeability Transition Pore (mPTP) and Induces Apoptotic Death of Colorectal Cancer Cells. PLoS One. 2016 May 12;11(5):e0154605. [3]. Xie Y, et al. Ferroptosis: process and function. Cell Death Differ. 2016 Mar;23(3):369-79.
CoA	CoA of Erastin

Smiles:	CCOC1=CC=CC=C1N1C(=O)C2=C(C=CC=C2)N=C1C(C)N1CCN(CC1)C(=O)COC1=CC=C(Cl)C=C1


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