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Product Information:

SIS3

SIS3 is a specific, cell-permeable, and selective Smad3 inhibitor, which inhibits Smad3 phosphorylation with an IC50 of 3 µM.

Cat. No.: EX-A1151    Purity: >98%
SIS3
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg450In-stock
250mg700In-stock
500mg1100In-stock
1g1500In-stock
5g4500Inquire


Synonyms(E)-SIS3
Synonyms 2SIS3 hydrobromide
CAS No.521984-48-5
Purity>98%
FormulaC28H28ClN3O3
Mol Weight489.993
Appearancewhite to off-white powder
SolubilityDMSO >20mg/mL
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Boudreau HE et al. Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-β-mediated migration of human lung and breast epithelial cells. Br J Cancer. 2014 May 13;110(10):2569-82.

[2]. Jinnin M et al. Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression. Mol Pharmacol. 2006 Feb;69(2):597-607.
CoACoA of SIS3
Smiles:Cl.COC1=CC2=C(CN(CC2)C(=O)\C=C\C2=C(N(C)C3=NC=CC=C23)C2=CC=CC=C2)C=C1OC

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