KU-57788

Potent and selective ATM kinase inhibitor IC50s= 13, 2500, 9300, 16600, >100000 and >100000 nM for ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively. Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21CIP1 levels in vitro. Disruption of ATM signaling in primary A-T fibroblasts leads to dysregulation of ribonucleotide reductase and increase resistance to inhibitors of mitochondrial respiration and translation. Sensitizes radio-resistant cancer cells.Provides neuroprotection against H2O2-induced cell damage.


Cat. No.: EX-A1331	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	600	In-stock
500mg	850	In-stock
1g	1250	In-stock
5g	Get quote

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CAS No.	503468-95-9
Purity	>98%
Formula	C25H19NO3S
Mol Weight	413.488
Appearance	solid powder
Solubility	Soluble in DMSO, not in water
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Hickson et al. (2004), Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM; Cancer Res., 64 9152 [2]. Crescenzi et al. (2008), Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy; Clin. Cancer Res. 14 1877 [3]. Eaton et al. (2007), Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis; J. Clin. Invest., 117 2723 [4]. Zhang et al. (2015) The ATM inhibitor KU55933 sensitizes radioresistant bladder cancer cells with DAB2IP gene defect; Int. J. Radiat. Biol., 91 368 [5]. Chwastek et al. (2017) The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a yH2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D; Int. J. Biochem. Cell Biol. 87 38
CoA	CoA of KU-57788

Smiles:	O=C1C=C(OC2=C1C=CC=C2C1=C2SC3=CC=CC=C3C2=CC=C1)N1CCOCC1


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