Mitomycin C

Mitomycin C is an antibiotic which acts as a double-stranded DNA alkylating agent. It covalently crosslinks DNA, inhibiting DNA synthesis and cell proliferation.


Cat. No.: EX-A501	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
200mg	785	In-stock
500mg	1085	In-stock
1g	1550	In-stock
5g	3150	In-stock

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CAS No.	50-07-7
Purity	>98%
Formula	C15H18N4O5
Mol Weight	334.3272
Appearance	purple solid powder
Solubility	DMSO ? 55 mM; Absolute ethanol ? 0.3 mM; PBS (pH 7.2) ? 1.5 mM
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Tomasz, M. Mitomycin C: small, fast and deadly (but very selective). Chemistry & biology vol. 2,9 (1995): 575-9. [2]. Crooke, S T, and W T Bradner. Mitomycin C: a review. Cancer treatment reviews vol. 3,3 (1976): 121-39. [3]. Pirnia, F et al. Mitomycin C induces apoptosis and caspase-8 and -9 processing through a caspase-3 and Fas-independent pathway. Cell death and differentiation vol. 9,9 (2002): 905-14. [4]. Paz, Manuel M et al. A new mechanism of action for the anticancer drug mitomycin C: mechanism-based inhibition of thioredoxin reductase. Chemical research in toxicology vol. 25,7 (2012): 1502-11.
CoA	CoA of Mitomycin C

Smiles:	CO[C@]12[C@H]3N[C@H]3CN1C1=C([C@H]2COC(N)=O)C(=O)C(N)=C(C)C1=O


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