background


Product Information:

NVP-AEW541

NVP-AEW541 is a potent inhibitor of IGF-1R with IC50 of 0.15 μM, also inhibits InsR, with IC50 of 0.14 μM.

Cat. No.: EX-A474    Purity: >98%
NVP-AEW541
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg590In-stock
250mg980In-stock
1g1950In-stock


SynonymsAEW541
CAS No.475489-16-8
Purity>98%
FormulaC27H29N5O
Mol Weight439.5521
AppearanceSolid powder
SolubilityDMSO >50mg/mL
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. García-Echeverría C, et al. In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell. 2004 Mar;5(3):231-9.

[2]. Tanno B, et al. Down-regulation of IGF-1 receptor activity by NVP-AEW541 has an antitumor effect on neuroblastoma cells in vitro and in vivo. Clin Cancer Res. 2006, 12(22), 6772-6780.
CoACoA of NVP-AEW541
Smiles:NC1=C2C(=CN([C@@H]3C[C@H](CN4CCC4)C3)C2=NC=N1)C1=CC=CC(OCC2=CC=CC=C2)=C1

KEYWORDS: buy NVP-AEW541 | NVP-AEW541 supplier | purchase | cost | manufacturer | order | distributor | buy 475489-16-8 | 475489-16-8 supplier