JAK Inhibitor I

A potent, cell-permeable, reversible, and ATP-competitive inhibitor of Janus protein tyrosine kinases (JAKs). Displays potent inhibitory activity against JAK1 (IC50 = 15 nM for murine JAK1), JAK2 (IC50 = 1 nM), JAK3 (Ki = 5 nM), and Tyk2 (IC50 = 1 nM). Inhibits other kinases at much higher concentrations. Shown to inhibit IL2- and IL4-dependent proliferation of CTLL cells and block the phosphorylation of STAT5, and further induce growth inhibition of multiple myeloma cells expressing activated JAKs and STAT3.


Cat. No.: EX-A123	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	450	In-stock
100mg	685	In-stock
250mg	985	In-stock
1g	1875	Inquire
5g	Get quote	Inquire

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Synonyms	Merck-5
Synonyms 2	Pyridone 6
CAS No.	457081-03-7
Purity	>98%
Formula	C18H16FN3O
Mol Weight	309.3375
Appearance	off-white solid
Solubility	DMSO: 5 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Pedranzini, L., et al. 2006. Cancer Res.66, 9714. [2]. Lucet, I.S., et al. 2005. Blood107, 176. [3]. Thompson, J.E., et al. 2002. Bioorg. Med. Chem. Lett.12, 1219.
CoA	CoA of JAK Inhibitor I

Smiles:	CC(C)(C)C1=NC2=C(N1)C1=C(C(=O)NC=C1)C1=CC(F)=CC=C21


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