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Product Information:

SKI606

Bosutinib is an orally active Src/Abl tyrosine kinase inhibitor with IC50 of 1.2 nM and 1 nM, respectively.

Cat. No.: EX-A391    Purity: >99.5%
SKI606
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
500mg285In-stock
1g385In-stock
5g860In-stock
10g1185In-stock


SynonymsBosutinib
Synonyms 2SKI-606
CAS No.380843-75-4
Purity>99.5%
FormulaC26H29Cl2N5O3
Mol Weight530.446
AppearanceSolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Jorge E Cortes, et al. Bosutinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: results from the BELA trial. J Clin Oncol. 2012 Oct 1;30(28):3486-92.

[2]. Miriam Puttini, et al. In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinib-resistant Bcr-Abl+ neoplastic cells. Cancer Res. 2006 Dec 1;66(23):11314-22.

CoACoA of SKI606
Smiles:COC1=C(Cl)C=C(Cl)C(NC2=C(C=NC3=CC(OCCCN4CCN(C)CC4)=C(OC)C=C23)C#N)=C1

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