YM201636

YM201636 is a selective PIKfyve inhibitor with IC50 of 33 nM, less potent to p110α and insensitive to Fabl (yeast orthologue). YM-201636 suppresses the growth of liver cancer via the induction of autophagy.


Cat. No.: EX-A037	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	495	In-stock
250mg	795	In-stock
500mg	1195	In-stock
1g	1795	In-stock
5g	6980	In-stock
10g	11280	In-stock

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CAS No.	371942-69-7
Purity	>98%
Formula	C25H21N7O3
Mol Weight	467.4793
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Jefferies, Harold B J et al. “A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding.” EMBO reports vol. 9,2 (2008): 164-70. [2]. Ikonomov, Ognian C et al. “YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes.” Biochemical and biophysical research communications vol. 382,3 (2009): 566-70. [3]. Dupuis-Coronas, Sophie et al. “The nucleophosmin-anaplastic lymphoma kinase oncogene interacts, activates, and uses the kinase PIKfyve to increase invasiveness.” The Journal of biological chemistry vol. 286,37 (2011): 32105-14.
CoA	CoA of YM201636

Smiles:	NC1=CC=C(C=N1)C(=O)NC1=CC=CC(=C1)C1=NC(N2CCOCC2)=C2OC3=NC=CC=C3C2=N1


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