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Product Information:

SB525334

SB 525334 is a potent and selective transforming growth factor β1 receptor (ALK5) inhibitor with an IC50 of 14.3 nM.

Cat. No.: EX-A256    Purity: >98%
SB525334
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg450In-stock
500mg650In-stock
1g985In-stock
2g1385In-stock
5g2150In-stock
10g3450In-stock


CAS No.356559-20-1
Purity>98%
FormulaC21H21N5
Mol Weight343.4249
Appearanceyellow to orange solid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Grygielko ET, et al. Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis. J Pharmacol Exp Ther, 2005, 313(3), 943-951.

[2]. Thomas M, et al. ALK5 mediates abnormal proliferation of vascular smooth muscle cells from patients with familial pulmonary arterial hypertension and is involved in the progression of experimental pulmonary arterial hypertension induced by monocrotaline.

[3]. Laping NJ, et al. Tumor-specific efficacy of transforming growth factor-beta RI inhibition in Eker rats. Clin Cancer Res, 2007, 13(10), 3087-3899.

CoACoA of SB525334
Smiles:CC1=CC=CC(=N1)C1=C(N=C(N1)C(C)(C)C)C1=CC=C2N=CC=NC2=C1

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