Decitabine

Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and a DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell apoptosis. Decitabine has potent anticancer activity.


Cat. No.: EX-A961	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	550	In-stock
500mg	700	In-stock
1g	850	In-stock
5g	1850	In-stock

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CAS No.	2353-33-5
Purity	>98%
Formula	C8H12N4O4
Mol Weight	228.2053
Appearance	solid powder
Solubility	Soluble in DMSO, H2O
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Nakamura M, et al. Decitabine inhibits tumor cell proliferation and up-regulates E-cadherin expression in Epstein-Barr virus-associated gastric cancer. J Med Virol. 2016 Jul 19. [2]. Parker WB. Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancer. Chem Rev. 2009 Jul;109(7):2880-93. [3]. Terse P, et al. Subchronic oral toxicity study of decitabine in combination with tetrahydrouridine in CD-1 mice. Int J Toxicol. 2014 Mar-Apr;33(2):75-85.
CoA	CoA of Decitabine

Smiles:	NC1=NC(=O)N(C=N1)[C@H]1C[C@H](O)[C@@H](CO)O1


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