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Product Information:

Bardoxolone

Bardoxolone is a novel nuclear regulator factor (Nrf-2) activator.

Cat. No.: EX-A1731    Purity: >98%
Bardoxolone
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg550In-stock
500mg685In-stock
1g885In-stock
2g1285In-stock
5g2800In-stock
10g4200In-stock


CAS No.218600-44-3
Purity>98%
FormulaC31H41NO4
Mol Weight491.6615
AppearanceSolid powder
SolubilityDMSO >50mg/mL
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. McCullough PA, et al. Cardiac and renal function in patients with type 2 diabetes who have chronic kidney disease: potential effectsof bardoxolone methyl. Drug Des Devel Ther. 2012;6:141-9.

[2]. Hong DS, et al. A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas. Clin Cancer Res. 2012 Jun 15;18(12):3396-406.

[3]. Reisman SA, et al. Bardoxolone Methyl Decreases Megalin and Activates Nrf2 in the Kidney. J Am Soc Nephrol. 2012 Oct;23(10):1663-73.

[4]. Dinh CH, et al. Bardoxolone Methyl Prevents Mesenteric Fat Deposition and Inflammation in High-Fat Diet Mice. ScientificWorldJournal. 2015;2015:549352.

CoACoA of Bardoxolone
Smiles:CC1(C)CC[C@@]2(CC[C@]3(C)[C@@H]([C@@H]2C1)C(=O)C=C1[C@@]2(C)C=C(C#N)C(=O)C(C)(C)[C@@H]2CC[C@@]31C)C(O)=O

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