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Product Information:

OTX015

Birabresib (OTX-015) is a potent bromodomain (BRD2/3/4) inhibitor with IC50s ranging from 92 to 112 nM.

Cat. No.: EX-A640    Purity: >98%
OTX015
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
500mg735In-stock
1g1050In-stock
2g1650In-stock
5g3500In-stock


SynonymsBirabresib
CAS No.202590-98-5
Purity>98%
FormulaC25H22ClN5O2S
Mol Weight491.992
AppearanceSolid powder
Solubilitysoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. J. Kay Noel, et al. Abstract C244: Development of the BET bromodomain inhibitor OTX015. Mol Cancer Ther November 2013 12; C244.

[2]. Marie-Magdelaine Coudé, et al. BET inhibitor OTX015 targets BRD2 and BRD4 and decreases c-MYC in acute leukemia cells. Oncotarget. 2015 Jul 10; 6(19): 17698–17712.

[3]. Lu P, et al. The BET inhibitor OTX015 reactivates latent HIV-1 through P-TEFb. Sci Rep. 2016 Apr 12;6:24100

[4]. Vázquez R, et al. The bromodomain inhibitor OTX015 (MK-8628) exerts anti-tumor activity in triple-negative breast cancer models as single agent and in combination with RAD001. Oncotarget. 2017 Jan 31;8(5):7598-7613.

CoACoA of OTX015
Smiles:CC1=NN=C2[C@H](CC(=O)NC3=CC=C(O)C=C3)N=C(C3=C(SC(C)=C3C)N12)C1=CC=C(Cl)C=C1

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